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The active ingredient present in Tadalift tablets by Pfizer is tadalafil - 20 mg.
Tadalafil does not directly cause penile erections, but affects the response to sexual stimulation. The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation and inflow of blood to the corpus cavernosum. Tadalafil enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE-5), which is responsible for degradation of cGMP in the corpus cavernosum; when sexual stimulation causes local release of NO, inhibition of PDE-5 by tadalafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. At recommended doses, it has no effect in the absence of sexual stimulation.
Also used to treat symptoms of benign prostatic hypertrophy (enlarged prostate), pulmonary arterial hypertension and improve exercise capacity in men and women.
Dosage and direction
Tadalift by Pfizer is taken 20 mg orally once per day at least one hour before an anticipated sexual encounter but not more than once per day. The dosage of Tadalift may vary from one user to another, depending on the doctor’s prescription.
Tadalafil can be taken with or without food.
Do not break or split a Tadalift tablet. Swallow it whole.
Tadalift can help achieve an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. Follow your doctor's instructions.
During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. You could be having a serious side effect of tadalafil.
Do not take Tadalift for erectile dysfunction if you are taking Adcirca for pulmonary arterial hypertension.
It is strongly recommended to consult your doctor or pharmacist before you start taking tadalafil and especially emphasize if you are allergic to this drug or if you take other medicines to treat pulmonary arterial hypertension, such as riociguat (Adempas).
Do not take tadalafil if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking tadalafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.
To make sure tadalafil is safe for you, tell your doctor if you have any of these other conditions: heart disease or heart rhythm problems, coronary artery disease; a recent heart attack (within the past 90 days); a recent history (in the past 6 months) of a stroke, or congestive heart failure; angina (chest pain), high or low blood pressure; liver or kidney disease (or if you are on dialysis); a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia; a bleeding disorder such as hemophilia; a stomach ulcer; retinitis pigmentosa (an inherited condition of the eye); a physical deformity of the penis (such as Peyronie's disease); or if you have been told you should not have sexual intercourse for health reasons.
Tadalafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people taking Viagra or other drugs similar to tadalafil. Most of these people also had certain pre-existing eye problems or risk factors for blood vessel disorders (such as heart disease, diabetes, high blood pressure, high cholesterol, coronary artery disease, smoking, or being over 50 years old). It is not clear whether tadalafil is the actual cause of vision loss.
Drinking alcohol while taking Tadalift can cause dangerous or unwanted side effects.
Grapefruit and grapefruit juice may interact with tadalafil and lead to unwanted side effects. Avoid the use of grapefruit products while taking Tadalift.
Avoid using any other medicines to treat impotence, such as alprostadil or yohimbine, without first talking to your doctor.
Possible side effect
Get emergency medical help if you have signs of an allergic reaction to Tadalift: hives, difficult breathing, your face, lips, tongue, or throat swelling.
Stop using tadalafil and get emergency medical help if you have: erection is painful or lasts longer than 4 hours (prolonged erection can damage the penis); vision changes or sudden vision loss; or heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.
Call your doctor at once if you have: ringing in your ears, or sudden hearing loss; irregular heartbeat; swelling in your hands, ankles, or feet; shortness of breath; seizure (convulsions); or a light-headed feeling, like you might pass out.
Commonly reported side effects of tadalafil include headache, dyspepsia, myalgia, nausea, back pain, limb pain, and flushing. Other side effects include upper respiratory tract infection, myalgia, back pain, nasal congestion, and cough. Some tadalafil side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them: acid or sour stomach; belching; heartburn; indigestion; stomach discomfort, upset, or pain
In case you notice any of these side effects or other not listed above - contact your doctor or pharmacist.
Consult your doctor before taking Tadalift by Pfizer. Tell your doctor about all your current medicines and any you start or stop using, especially: an antibiotic or antifungal medicine; antiviral medicine to treat hepatitis C or HIV/AIDS; drugs to treat high blood pressure or a prostate disorder; seizure medicine.
This list is not complete. Other drugs may interact with tadalafil including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Contact your doctor or pharmacist for more details.
If tadalafil is used as needed, you are not likely to be on a dosing schedule. If you take tadalafil every day and you miss a dose, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
If you think you have used too much of Tadalift - seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Store Tadalift at room temperature 77° F (20-25° C). Store away from moisture and heat. Do not store drugs in the bathroom. Keep all drugs out of the reach children and pets.
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.